Parameter | Unit | 10 mg/kg (N_{obs} = 5) | 20 mg/kg (N_{obs} = 3) |
---|---|---|---|
AUC_{0–∞} | μg × h/mL | 14,200 (31.9) | 70,000 (56.9) |
C _{max} | μg/mL | 179 (43.2) | 479 (12.0) |
t _{1/2} ^{a} | h | 97.0 (34.3) | 341 (83.2) |
CL | mL/h/kg | 0.703 (28.4) | 0.286 (43.4) |
V _{ss} | mL/kg | 89.4 (36.0) | 139 (16.5) |
Abbreviations: CL, total systemic clearance; N _{obs}, number of observations used in the calculation; V _{ss}, volume of distribution at steady state.
↵ ^{a} t _{1/2}, harmonic mean.